The expression of P2Y ₆ receptor promotes the quality of mucus in colitic mice

In the intestine, mucins are expressed and secreted by goblet cells enterocytes in a constitutive manner response to secretagogues form protective mucus layer. This barrier is often lost inflammatory bowel disease (IBD). Interestingly, extracellular nucleotides, through P2Y receptors, were identified as mucin mucinous epithelia. These nucleotides found intestine’s milieu under basal conditions higher concentrations pathologies such IBD. It was observed that layer affected P2ry6 knockout mice suffering from dextran sodium sulfate (DSS)-induced colitis. P2ry6−/− more sensitive DSS-induced colitis, resulting larger ulcers increased activity index. absence of P2Y6 receptor expression negatively quality, shown reduction sulfomucin staining dense internal fucosylated mice. Hence, we cannot rule out receptors animals could impact secretion. However, did not measure number cells, previously reported. Instead, results suggest rapidly discharged compensate for layer's lability, which resulted empty less visible staining. study's results, along with previous reports, point toward role